The last 50 years have enabled significant progress in our ability to describe and model both the oceanic and atmospheric environments of the Indian Ocean and their interactions with the sea floor and coastal regimes. However, our understanding of the major processes of the Indian Ocean is still far from complete and is rudimentary in many respects. This SI compiles various synthesis articles about the recent results of the 2nd International Indian Ocean Expedition Program (IIOE-2: https://iioe-2.incois.gov.in/). The synthesis articles will review and highlight results of physical, biogeochemical, ecological, geological, coastal and atmospheric studies from all parts of the Indian Ocean. Moreover, the SI will serve to illustrate some of the key questions that are relevant for future research on the grand challenges in the Indian Ocean system.