Ground-level ozone (O₃), heat, and water stress (WS) reduce wheat yields, threatening food security in India. O₃, heat, and WS interact as stressed plants close stomata, limiting O₃ entry and damage. This study models O₃ uptake under rainfed (WS) and irrigated conditions for current and future climates. Results show little O₃-related yield loss under WS but higher losses with irrigation. Both climate scenarios increase O₃-related losses, highlighting risks to India’s wheat productivity.